Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia.
Journal of translational medicine(2017)
Abstract
The identification of molecular pathways involved in the pathogenesis of sarcopenia open new prospective for the development of drugs able to prevent/treat the muscle impairment that occur in elderly. Results here reported, highlighting the role of BMPs and myostatin pathways in physio-pathogenesis of human sarcopenia, allow us to propose human recombinant BMP-2/7 and anti-myostatin antibodies as a possible therapeutic option for the sarcopenia.
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Key words
Satellite Cell, Joint Space Narrowing, Muscle Quality, Atrophic Fiber, CTRL Group
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