Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling.

Helle Sadam,Arno Pihlak,Anri Kivil,Susan Pihelgas,Mariliis Jaago,Priit Adler,Jaak Vilo,Olli Vapalahti,Toomas Neuman,Dan Lindholm,Markku Partinen,Antti Vaheri,Kaia Palm

EBioMedicine（2018）

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摘要

•Using large-scale antibody profiling, differences between narcolepsy type 1 (NT1) and healthy controls became evident.•Prostaglandin D2 receptor DP1 was delineated as a novel autoantigenic target in NT1.•Utility of a 3-biomarker ELISPOT assay to assess exposure to H1N1 influenza virus and susceptibility to NT1 was demonstrated.

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关键词

Narcolepsy type 1,H1N1,Pandemrix,Antibody,Prostaglandin,DP1

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