The effects of lead exposure on the expression of HMGB1 and HO-1 in rats and PC12 cells.

Meiyuan Yang,Yaobin Li,Ying Wang,Nuo Cheng,Yi Zhang,Shimin Pang,Qiwei Shen,Lijuan Zhao,Guilin Li,Gaochun Zhu

Toxicology Letters（2018）

引用 15|浏览5

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摘要

•We have demonstrated a correlation between in vivo and in vitro exposure to Pb in rats and PC-12 cells.•Pb exposure up-regulated the expression of HO-1 and HMGB1in rats and PC12 cells.•The effect of Pb on HMGB1 may through regulate HO-1expression in the PC12 cells.

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关键词

Lead,High mobility group histone B1,Heme oxygenase-1

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