PTH (1-34) affects bone turnover governed by osteocytes exposed to fluoride.

Xiuhua Yu,Haolan Yu,Ningning Jiang,Xiuyun Zhang,Mengmeng Zhang,Hui Xu

Toxicology Letters（2018）

引用 8|浏览5

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摘要

•Osteocytes endured high dose of fluoride exposure.•Fluoride inhibited expression of SOST/Sclerostin in osteocytes.•Fluoride modulated ratio of RANKL/OPG in osteocytes.•Fluoride regulated Wnt/β-catenin signaling in osteocytes.•PTH(1–34) participated in fluoride-modulating SOST and RANKL expression in osteocytes.

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关键词

Fluorides,Parathyroid hormone,Osteocytes,Sclerostin protein,RANK ligand

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