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A Single N-terminal Phosphomimic Disrupts TDP-43 Polymerization, Phase Separation, and RNA Splicing

Ailin Wang,Alexander E. Conicella,Hermann Broder Schmidt,Erik W. Martin,Shannon N. Rhoads,Ashley N. Reeb,Amanda Nourse,Daniel Ramirez Montero,Veronica H. Ryan,Rajat Rohatgi,Frank Shewmaker,Mandar T. Naik,Tanja Mittag,Yuna M. Ayala,Nicolas L. Fawzi

The EMBO Journal（2018）

引用 307|浏览43
关键词
amyotrophic lateral sclerosis,protein-protein interaction,RNA splicing,RNP granule,solution NMR spectroscopy
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