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Trans-suppression of host CDH3 and LOXL4 genes during Cryptosporidium parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA

Zhenping Ming,Ai-Yu Gong,Yang Wang,Xin-Tian Zhang,Min Li, Yao Li, Jing Pang, Stephanie Dong,Juliane K. Strauss-Soukup,Xian-Ming Chen

International Journal for Parasitology（2018）

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Abstract
•Cryptosporidium parvum infection causes downregulation of CDH3 and LOXL4 genes in host intestinal epithelial cells.•A parasite RNA Cdg7_FLc_1000 is recruited to the promoter regions of both CDH3 and LOXL4 gene loci following infection.•Cdg7_FLc_1000 promotes PRDM1/G9a-mediated H3K9 methylation associated with trans-suppression of CDH3, but not LOXL4.
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Key words
Cryptosporidium,Intestinal epithelium,CDH3,LOXL4,Gene transcription,Epithelial homeostasis
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