Identification of risk factors for sessile and traditional serrated adenomas of the colon by using big data analysis.

Background and AimLittle is known about the risk factors associated with serrated polyps, because the early studies, which occurred before the new World Health Organization classification was introduced, included mixtures of serrated polyps. This study aimed to evaluate the risk factors associated with the presence of sessile serrated adenomas (SSAs) and traditional serrated adenomas (TSAs) using big data analytics. MethodsUsing a case-control design, we evaluated the risk factors associated with the presence of SSAs and TSAs. Subjects who underwent colonoscopies from 2002 to 2012 as part of the comprehensive health screening programs undertaken at the Samsung Medical Center, Korea, participated in this study. ResultsOf the 48677 individuals who underwent colonoscopies, 183 (0.4%) had SSAs and 212 (0.4%) had TSAs. The multivariate analysis determined that being aged 50years (odds ratio [OR] 1.91, 95% confidential interval [CI] 1.27-2.90, P=0.002) and a history of colorectal cancer among first-degree relatives (OR 3.14, 95% CI 1.57-6.27, P=0.001) were significant risk factors associated with the presence of SSAs and that being aged 50years (OR 2.61, 95% CI 1.79-3.80, P<0.001), obesity (OR 1.63, 95% CI 1.12-2.36, P=0.010), and a higher triglyceride level (OR 1.63, 95% CI 1.12-2.36, P=0.010) were independent risk factors associated with the presence of TSAs. ConclusionsWe used big data analytics to determine the risk factors associated with the presence of specific polyp subgroups, and individuals who have these risk factors should be carefully scrutinized for the presence of SSAs or TSAs during screening colonoscopies.