Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is an independent risk factor for diabetes mellitus: results from a population-based cohort.

BackgroundDyslipidemia predicts the development and progression of diabetes. A higher non-high-density lipoprotein cholesterol (HDL-C):HDL-C ratio is reportedly associated with metabolic syndrome and insulin resistance, but its relationship with glycemic levels and diabetes remains unclear. MethodsIn all, 4882 subjects aged 40years without diabetes and not using lipid-lowering drugs were enrolled in the study. The non-HDL-C:HDL-C ratio was log(10) transformed to achieve normal distribution. Multivariate logistic regression was used to investigate the association between the log(10)-transformed non-HDL-C:HDL-C ratio and diabetes. Stratified analyses of the association by age, gender, and body mass index (BMI) were also performed. ResultsAfter 3years of follow-up, 704 participants developed diabetes. After adjustment for age, gender, current smoking, current drinking, physical activity, BMI, systolic blood pressure, and family history of diabetes, each 1-SD increase in the log(non-HDL-C:HDL-C ratio) was associated with higher fasting blood glucose (FPG) levels (=0.1; 95% confidence interval [CI] 0.1-0.1), 2-h postload plasma glucose levels (2-h glucose; =0.2; 95% CI 0.1-0.2), and risk of diabetes (odds ratio [OR] 1.1; 95% CI 1.0-1.2). In a multivariate model, subjects in the top quartile of non-HDL-C:HDL-C ratio had higher FPG (=0.2; 95% CI 0.2-0.3), 2-h glucose (=0.5; 95% CI 0.3-0.7) and HbA1c (=0.1; 95% CI 0.1-0.2) levels, and a 40% increased risk of diabetes (OR 1.4; 95% CI 1.1-1.8) than participants in the bottom quartile. ConclusionsThe non-HDL-C:HDL-C ratio was found to be an independent risk factor for diabetes.