A highly specific SpCas9 variant is identified by in vivo screening in yeast

Antonio Casini,Michele Olivieri,Gianluca Petris,Claudia Montagna,Giordano Reginato,Giulia Maule,Francesca Lorenzin,Davide Prandi,Alessandro Romanel,Francesca Demichelis,Alberto Inga,Anna Cereseto

NATURE BIOTECHNOLOGY（2018）

引用 333|浏览45

暂无评分

摘要

Evolved SpCas9 variant evoCas9 has improved specificity and retains near wild-type on-target activity.

查看译文

关键词

Gene targeting,Gene therapy,Genetic engineering,Protein design,Life Sciences,general,Biotechnology,Biomedicine,Agriculture,Biomedical Engineering/Biotechnology,Bioinformatics

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要