Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever.

Anna Lacasta,Stephen Mwalimu, Elisabeth Kibwana,Rosemary Saya,Elias Awino,Thomas Njoroge,Jane Poole,Nicholas Ndiwa,Roger Pelle,Vishvanath Nene,Lucilla Steinaa

Vaccine（2018）

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摘要

•Three doses of p67C antigen generated stronger immune responses than two doses.•Antibody titers and CD4+ T-cell proliferation correlated with protection against ECF.•The number of doses could not be reduced from three to two without compromising the protection.

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关键词

East Coast fever,Vaccinology,Subunit vaccine,Parasite,p67C antigen,Theileria parva

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