[Cancers associated with systemic sclerosis involving anti-RNA polymerase III antibodies].

Background. - The incidence of cancer is increased in patients with systemic sclerosis (SSc). Further, recent studies have also shown that the presence of anti-RNA polymerase III antibodies is associated with a higher incidence of cancer in this population. Patients and methods. - Herein we present the cases of two men aged 56 and 23 years presenting SSc without anti-Scl70 or anti-centronnere antibodies but with anti-RNA polymerase III antibodies. Clinical symptoms led us to prescribe more laboratory exams and both patients were diagnosed with cancer of the nasopharyngeal area. Discussion. - Anti-RNA polymerase III antibodies are useful for SSc diagnosis in patients without anti-centromere or anti-Scl70 antibodies. Their presence must lead physicians to screen for associated cancer, even in the absence of clinical signs. (C) 2017 Elsevier Masson SAS. All rights reserved.