Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics.

Priya D Shanmugarajah,Nigel Hoggard,Daniel P Aeschlimann,Pascale C Aeschlimann,Gary J Dennis,Stephen J Howell,Markus Reuber,Richard A Grünewald,Marios Hadjivassiliou

Seizure（2018）

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摘要

•Ataxia is present in 40% patients with epilepsy and chronic exposure to phenytoin•Patients on phenytoin have cerebellar degeneration even if they have no ataxia•Gait, stance and heel-shin slide ataxia were the predominant clinical features•Structural deficits on imaging suggest a predilection for vermian involvement

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关键词

AED,AGA,EMA,HLA,MRI,NAA/Cr,PHT,PHTA,SARA,TG2,TG6

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