A membrane-type surfactant protein D (SP-D) suppresses macrophage-mediated cytotoxicity in swine endothelial cells.

Patmika Jiaravuthisan,Akira Maeda,Chihiro Takakura,Han-Tang Wang,Rieko Sakai,Afifah Mohd Shabri,Pei-Chi Lo,Rei Matsuura,Tasuku Kodama,Hiroshi Eguchi,Hiroomi Okuyama,Shuji Miyagawa

Transplant Immunology（2018）

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摘要

•A hybrid molecule derived from SP-D and CL-1, Flag-tagged CL-SP-D, can be expressed on SEC.•The CL-SP-D significantly reduced macrophage-mediated cytotoxicity against SEC.•Phosphorylated SHP-1 was clearly detected in SEC with CL-SP-D by western blots.•IL-10 production was upregulated and IL-1β was suppressed in SEC with CL-SP-D.

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关键词

SP-D,Xenotransplantation,Macrophage,THP-1,SIRPα

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