Sleep deprivation precipitates the development of amphetamine-induced conditioned place preference in rats.

•2 conditionings with amphetamine did not induce conditioned place preference (CPP).•Sleep deprivation during conditioning trials precipitated amphetamine-induced CPP.•Sleep deprivation-induced potentiation of CPP was not dissipated across the session.•Lack of sleep contributes to the establishment of a drug-environment conditioning.•Our data suggest that sleep deprivation potentiates amphetamine reward.