Targeted delivery of SNX-2112 by polysaccharide-modified graphene oxide nanocomposites for treatment of lung cancer.

Xuan Liu,Xiaozhen Cheng,Fengzhe Wang,Longbao Feng,Yu Wang,Yanfang Zheng,Rui Guo

Carbohydrate Polymers（2018）

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摘要

•GO-CHI-HA was loaded with an anti-cancer drug SNX-2112.•GO-CHI-HA/SNX-2112 proved to be effective in inhibiting and killing A549 cells.•GO-CHI-HA/SNX-2112 caused no severe long-term injury towards vital organs in SD rats.

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关键词

Graphene oxide,Polysaccharide,Lung cancer,Drug delivery,Biocompatibility

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