Acute stress regulates phosphorylation of N-methyl-d-aspartate receptor GluN2B at S1284 in hippocampus.

•Forced swimming elicits robust increase in pS1284 level of GluN2B.•Acute restraint for 6h rather than 1h induces a marked increment of pS1284 level.•Roscovitine negates changes of pS1284 level in forced swimming and acute restraint.•Roscovitine reduces the immobility time of mice during forced swimming test.