Investigation of the spatial structure and interactions of the genome at sub-kilobase-pair resolution using T2C

Petros Kolovos,Rutger W W Brouwer,Christel E M Kockx,Michael Lesnussa,Nick Kepper,Jessica Zuin, A M Ali Imam,Harmen J G van de Werken,Kerstin S Wendt,Tobias A Knoch,Wilfred F J van IJcken,Frank Grosveld

NATURE PROTOCOLS（2018）

引用 13|浏览44

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摘要

This protocol describes targeted chromatin capture (T2C), a high-resolution method to interrogate 3D chromatin organization and genomic interactions at sub-kilobase-pair resolution that requires minimal cell numbers and sequencing depth.

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关键词

Bioinformatics,Chromatin structure,Chromosome conformation capture-based methods,Genetic techniques,Life Sciences,general,Biological Techniques,Analytical Chemistry,Microarrays,Computational Biology/Bioinformatics,Organic Chemistry

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