Metal-Organic Framework Modified Glass Substrate for Analysis of Highly Volatile Chemical Warfare Agents by Paper Spray Mass Spectrometry.

Paper spray mass spectrometry (PS-MS) has been shown to successfully analyze chemical warfare agent (CWA) simulants. However, due to the volatility differences between the simulants and real G-series (i.e. sarin, soman) CWAs, analysis from an untreated paper substrate proved difficult. In order to extend the analytical lifetime of these G-agents, metal-organic frameworks (MOFs) were successfully integrated onto the paper spray substratesto increase adsorption and desorption. In this study, several MOFs and nanoparticles were tested to extend the analytical lifetime of sarin, soman, and cyclosarin on paper spray substrates. It was found that the addition of either UiO-66 or HKUST-1 to the paper substrate increased the analytical lifetime of the G-agents from less than five minutes detectability to at least 50 minutes.