A broad investigation of the HBV-mediated changes to primary hepatocyte physiology reveals HBV significantly alters metabolic pathways.

R Jason Lamontagne,Jessica C Casciano,Michael J Bouchard

Metabolism（2018）

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摘要

•First global analysis of HBV-mediated changes in the primary hepatocyte metabolome•First global analysis of HBx-mediated changes in the primary hepatocyte metabolome•HBV and HBx alter primary hepatocyte lipid, long-chain fatty acid metabolism.•HBV and HBx alter primary hepatocyte glycolysis.•HBV and HBx alter primary hepatocyte glycogen metabolism.

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