Interleukin-6 potentiates FcεRI-induced PGD biosynthesis and induces VEGF from human in situ-matured skin mast cells.

Cody McHale,Zahraa Mohammed,Juline Deppen,Gregorio Gomez

Biochimica et Biophysica Acta (BBA) - General Subjects（2018）

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摘要

•Human skin mast cells constitutively express membrane-bound IL-6Rα and gp130.•IL-6 potentiates FcεRI-induced PGD2 biosynthesis in human skin mast cells.•IL-6 enhances FcεRI-induced COX‑2 expression and PGD2 biosynthesis by a STAT3 dependent mechanism.•IL-6 induces de novo production of VEGF in human skin mast cells by a STAT3 dependent mechanism.•IL-6 enhances FcεRI-induced IL-8 production from human skin mast cells.

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关键词

IgE,PGD2,COX‑1,COX‑2,IL-6,VEGF,CBMCs

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