Inhibition of microglial activation with minocycline at the intrathecal level attenuates sympathoexcitatory and proarrhythmogenic changes in rats with chronic temporal lobe epilepsy.

Amol M Bhandare,Komal Kapoor,Kim L Powell,Emma Braine,Pablo Casillas-Espinosa,Terence J O'Brien,Melissa M J Farnham,Paul M Pilowsky

Neuroscience（2017）

引用 27|浏览3

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摘要

•Epilepsy-induced altered cardiovascular function, regulated by autonomic nervous system, is a major cause of death.•Chronic spontaneous seizures in rats produce profound proarrhythmogenic effects.•In epileptic rats, proarrhythmogenic and sympathoexcitatory effects are mediated by action of microglia at spinal cord.•Neither PACAP nor microglia regulate the major cardiovascular reflex responses in epileptic rats.•Modifying the microglial activity in epileptics might produce sympathoprotective and eventually cardioprotective effects.

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关键词

AUC,CD,ECG,HR,Iba1,IML,Ir,IT,KA,MAP,O.D.,PACAP,PaCO2,PBS,Post-SE,QT interval,QTc,RVLM,SE,SNA,SUDEP,TH,TLE

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