New α-Pyridones with Quorum Sensing Inhibitory Activity from Diversity-Enhanced Extracts of a Marine Algae-Derived Streptomyces sp.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY(2018)
Abstract
Four new alpha-pyrones (1-4) and eight known analogues (5-12) were identified from the secondary metabolites of Streptomyces sp. OUCMDZ-3436 derived from the marine green algae Enteromorpha prolifera. Seven new alpha-pyridones (14-20) were constructed by diversity-oriented synthesis, which has been an effective approach to expanding the chemical space of natural-product-like compounds. Compounds 16, 17, 19, and 20 were found to have inhibitory effect on the gene expression controlled by quorum sensing in Pseudomonas aeruginosa QSIS-lasI.
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Key words
pyridone,QS-inhibition,diversity-enhanced extracts,Streptomyces sp,Enteromorpha prolifera
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