Survey For The Real-World-Practice And Expectation Of Asia-Pacific Physicians And Patients In Helicobacter Pylori Eradication (Reap-Hp Survey)

ObjectiveThe aims of the study were: 1, to survey the most popular anti-H.pylori regimens in Asia-Pacific region and the real-world effectiveness of these regimens; and 2, to investigate the expectation gaps of eradication rate between physicians and patients.DesignA questionnaire was distributed to Asia-Pacific physicians who attended the Asia-Pacific Digestive Week 2015 meeting. Reported eradication rates from the literatures were compared with real-world rates of surveyed popular regimens within the region. In addition, a questionnaire was distributed to H.pylori-infected patients in three regions of Taiwan.ResultsA total of 691 physicians and 539 patients participated in the survey. The top five most commonly used regimens were 7-day clarithromycin-based standard triple therapy (50.4%), 14-day clarithromycin-based standard triple therapy (31.0%), 10-day sequential therapy (6.1%), 14-day bismuth quadruple therapy (3.9%), and 14-day hybrid therapy (3.6%). All countries except for China had a significant gap between the expectation of physicians on anti-H.pylori therapy and the real-world eradication rate of most commonly adopted regimens (all P value <.05). The expectation on minimal eradication rate among patients was higher than that of physicians (91.4% vs 86.5%, P<.001).ConclusionsIt is time for physicians in Asia-Pacific countries to adopt newer and more efficacious anti-H.pylori regimens to meet the Kyoto consensus recommendation and their patients' expectations.