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The choice of linker for conjugating R848 to inactivated influenza virus determines the stimulatory capacity for innate immune cells.

Marlena M Westcott,Elene A Clemens,Beth C Holbrook,S Bruce King,Martha A Alexander-Miller

Vaccine（2018）

Cited 10|Views8
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Abstract
•Inactivated flu virus modified with GMBS-R848 is a potent activator of human DC.•The activity of an R848-influenza conjugate is greatly impacted by crosslinker choice.•Poor vaccine responsiveness may be overcome with high DC stimulatory capacity.
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Key words
Influenza,Vaccine,Toll-like receptor,R848,Adjuvant,Dendritic cell
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