Site- and species-specific hydrolysis rates of cocaine.

•Protonation macro- and microconstants of cocaine and its derivatives were determined.•Site- and species-specific hydrolysis rate constants of cocaine and its hydrolysis products were detemined.•The experiments were performed with NMR spectroscopy.•Nitrogen protonation accelerates the hydrolyses approximately 10 times both at site 2 and site 3.