Multidrug-Resistant Shigella Infections in Patients with Diarrhea, Cambodia, 2014-2015.

Kamonporn Poramathikul,Ladaporn Bodhidatta,Sivhour Chiek,Wilawan Oransathid,Sirigade Ruekit,Panida Nobthai,Woradee Lurchachaiwong,Oralak Serichantalergs,Chanthap Lon,Brett Swierczewski

EMERGING INFECTIOUS DISEASES（2016）

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Abstract

We observed multidrug resistance in 10 (91%) of 11 Shigella isolates from a diarrhea! surveillance study in Cambodia. One isolate was resistant to fluoroquinolones and cephalo-sporins and showed decreased susceptibility to azithromycin. We found mutations in gyrA, parC, beta-lactamase, and mphA genes. Multidrug resistance increases concern about shigellosis treatment options.

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Key words

Cambodia,MDR genes,Shigella,antimicrobial resistance,bacteria,bacterial infections,dysentery,enteric infections

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