IL-17A enhances IL-13 activity by enhancing IL-13-induced signal transducer and activator of transcription 6 activation.

Sara L Hall,Theresa Baker,Stephane Lajoie,Phoebe K Richgels,Yanfen Yang,Jaclyn W McAlees,Adelaide van Lier,Marsha Wills-Karp,Umasundari Sivaprasad,Thomas H Acciani,Timothy D LeCras,Jocelyn Biagini Myers,Melinda Butsch Kovacic,Ian P Lewkowich

Journal of Allergy and Clinical Immunology（2017）

引用 62|浏览44

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摘要

Our data suggest that IL-17A contributes to asthma pathophysiology by increasing the capacity of IL-13 to activate intracellular signaling pathways, such as signal transducer and activator of transcription 6. These data represent the first mechanistic explanation of how IL-17A can directly contribute to the pathogenesis of IL-13-driven pathology.

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关键词

Asthma,IL-13,IL-17A,signal transducer and activator of transcription 6,cytokines,signal transduction

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