Enzymatic cleavage promotes disassembly of GII.3 norovirus virus like particles and its binding to salivary histo-blood group antigens.

Yuqi Huo,Wenhui Wang,Lijun Zheng,Xuhui Chen,Shuo Shen,Mingchen Wang

Virus Research（2017）

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摘要

•Fecal extracts promote the binding of GII.3 VLPs to salivary histo-blood group antigens (HBGAs).•Enzyme cleavage is required for the observed promotion effects.•The binding of cleaved GII.3 VLPs derived from VP1 of different strains against salivary HBGAs can be blocked by rabbit anti-JZ402 hyperimmune serum.

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关键词

Histo-blood group antigens,GII.3 Norovirus,Fecal extract,Capsid protein cleavage

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