Safety and PK/PD correlation of TV-1106, a recombinant fused human albumin-growth hormone, following repeat dose administration to monkeys.

•TV-1106 is a long acting recombinant GH which was tested pre-clinically.•Treated animals showed no adverse effects and IGF-1 serum levels were elevated.•There was a clear correlation between change in IGF-1 levels and TV-1106 exposure.•TV-1106 was shown to be safe, long acting and pharmacodynamically active.