Anti-apoptotic activity of human matrix Metalloproteinase-2 attenuates diabetes mellitus.

Kota Nishihama,Taro Yasuma,Yutaka Yano,Corina N D' Alessandro-Gabazza,Masaaki Toda,Josephine A Hinneh,Prince Baffour Tonto,Atsuro Takeshita,Toshiaki Totoki,Rumi Mifuji-Moroka,Tetsu Kobayashi,Motoh Iwasa,Yoshiyuki Takei,John Morser,Isaac Cann,Esteban C Gabazza

Metabolism（2018）

引用 17|浏览34

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摘要

•Metalloproteinase-2 is increased in diabetes but its significance is unclear.•Metalloproteinase-2 inhibits β-cell apoptosis and improves glucose control in vitro and in vivo.•The integrin-β3/Akt/Bad pathway mediates the protective activity of metalloproteinase-2.

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关键词

MMP2,TG,STZ,DOX,NF,FCS,HUVECs,NHMCs,EDTA,WT,SAL

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