Antioxidant property of HDL as well as cholesterol efflux capacity are independent risk markers for atherosclerotic cardiovascular disease in patients with familial hypercholesterolemia.

Aim: Interventions or genetic variants that raise HDL cholesterol do not reduce risk of atherosclerotic cardiovascular disease (ASCVD). Therefore, studies of HDL functionalities rather than HDL cholesterol levels are encouraged. We previously reported that cholesterol efflux capacity was independently and inversely associated with the presence of ASCVD in 227 familial hypercholesterolemia (FH) patients. Accordingly, we aimed to investigate the association between antioxidant property of HDL, another functionality, and the presence of ASCVD in 332 statin-treated heterozygous FH patients.