Palmitoylethanolamide promotes anti-inflammatory phenotype of macrophages and attenuates plaque formation in ApoE-/- mice
ATHEROSCLEROSIS(2016)
Abstract
Aim: The endogenous fatty acid amide palmitoylethanolamide (PEA) is a lipid-derived mediator, which does not bind to the cannabinoid receptors CB1 and CB2, but exerts potent anti-inflammatory effects by ligating type-α peroxisome proliferator-activated receptors (PPAR-α). PEA has shown to possess therapeutic potential in inflammatory disease models, but the role of PEA and its promise as a therapeutic agent in atherosclerosis remain unexplored. We aimed to evaluate the therapeutic potential of chronic PEA treatment in atherosclerotic mice.
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Key words
palmitoylethanolamide,macrophages,plaque formation,anti-inflammatory
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