C2'-F Stereoconfiguration as a puckering switch for base stacking at the dinucleotide level.
JOURNAL OF ORGANIC CHEMISTRY(2018)
Abstract
Fluorine configuration at C2' of the bis(2'-fluorothymidine) dinucleotide is demonstrated to drive intramolecular base stacking. 2'-beta F-Configuration drastically reduces stacking compared to the 2'-alpha series. Hence, base stacking emerges as being tunable by the C2'-F stereoconfiguration through dramatic puckering variations scrutinized by NMR and natural bond orbital analysis. Accordingly, 2'-beta F-isomer photoreactivity is significantly reduced compared to that of the 2'-alpha F-isomer.
MoreTranslated text
Key words
stereoconfiguration,base stacking,puckering switch
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined