Alterations In Spontaneous Delta And Gamma Activity Might Provide Clues To Detect Changes Induced By Amyloid- Administration

Alzheimer's disease (AD) is the most prevalent form of dementia and has an increasing incidence. The neuropathogenesis of AD is suggested to be a result of the accumulation of amyloid- (A) peptides in the brain. To date, A-induced cognitive and neurophysiologic impairments have not been illuminated sufficiently. Therefore, we aimed to examine how spontaneous brain activities of rats changed by injection of increasing A doses into the brain hemispheres, and whether these changes could be used as a new biomarker for the early diagnosis of the AD. Rats were randomized into following groups: sham (Sham) and seven A-treated (i.c.v.) groups in increasing concentrations (from A-1 to A-7). After recovery, EEG recordings were obtained from implanted electrodes from eight electrode locations, and then, spectral and statistical analyses were performed. A significant decrement in gamma activity was observed in all A groups compared with the sham group. In delta activity, we observed significant changes from A-4 to A-7 group compared with sham group. Delta coherence values were decreased from A-4 to A-7 and A-5 to A-7 groups for frontal and temporal electrode pairs, respectively. A gradual increment was observed in A(1-42) level till A-4 group. Positive correlation for global delta power and negative correlation for global gamma power between A(1-42) peptide levels were detected. Consequently, it is conceivable to suggest gamma oscillation might be used to detect early stages of AD. Moreover, changes in delta activity provide information about the onset of major pathologic changes in the progress of AD.