Reasons for Failure of Systemic-to-Pulmonary Artery Shunts in Neonates.

Background Systemic-to-pulmonary artery shunt placement is an established palliative procedure for congenital heart disease. Although it is thought to be a simple operation, it is associated with significant morbidity and mortality. Methods Data for all neonates who underwent surgery for a systemic-to-pulmonary artery shunt between 2000 and 2016 were reviewed. The study endpoints were shunt failure and shunt-related mortality. Shunt failure was defined as a shunt dysfunction because of thrombosis or stenosis requiring intervention or reoperation; shunt mortality was defined as death because of a shunt dysfunction. Results A total of 305 shunts (central shunt, n =135; Blalock-Taussig shunt, n =170) were implanted in 280 patients. The median patients' age at the time of surgery was 9 days (1-31 days). The median shunt size was 3.5mm (3-4 mm). Twenty-four patients (8%) were diagnosed with a shunt failure, with a median time of 7 days (0-438 days). Freedom from shunt failure at 1year was 91.6%2%. A shunt-related mortality was ascertained for 12 patients (4%). Freedom from shunt-related mortality at 1year was 96%+/- 1%. Perioperative platelet transfusion ( p =0.01), central shunt ( p =0.02), 3-mm shunt size ( p =0.02), and postoperative extra corporeal membrane oxygenation (ECMO) ( p <0.01) were identified as risk factors for shunt failure. Platelet transfusion ( p =0.04) and postoperative ECMO ( p <0.01) were further identified as risk factors for shunt mortality. Conclusion Based on these data, we recommend implanting a modified Blalock-Taussig shunt of at least 3.5mm in neonates. Perioperative platelet transfusion and postoperative ECMO increase the risk of shunt failure.