The association analysis of TLR2 and TLR4 gene with tuberculosis in the Tibetan Chinese population.

Background: The present study was undertaken to explore the relationship of Toll-like receptor (TLR) 2, TLR4 genes polymorphisms with Pulmonary tuberculosis (PTB) risk in a sample of Chinese population. Methods: For this study, we recruited 467 subjects with PTB and 504 healthy subjects from a Tibetan population living in near or in Xi'an, China. Association analyses of single-nucleotide polymorphisms (SNPs) in TLR2 and TLR4 were performed with SPSS Statistics (version 17.0), SNPStats, Haploview (version 4.2), and SHEsis software. Results: The research results that is association analysis of pulmonary tuberculosis show there are two increased-risk SNPs (rs7696323, OR=1.32, 95% CI = 1.08-1.62, P= 0.007; rs12377632, OR=1.30, 95% CI = 1.09-1.55, P= 0.004) and three decreased-risk SNPs (rs3804099, OR=0.64, 95% CI = 0.52-0.79, P= 1.95*10(-5); rs3804100, OR=0.67, 95% CI = 0.54-0.82, P= 0.0001; rs11536889, OR=0.54, 95% CI = 0.42-0.69, P= 9.14*10(-7)). Conclusions: We found that two SNPs are associated with increased PTB risk and three SNPs decreased PTB risk in the Chinese Tibetan population. Our findings demonstrate an association between TLR2 and TLR4 polymorphisms and PTB.