Differential insulin and steroidogenic signaling in insulin resistant and non- insulin resistant human luteinized granulosa cells - a study in PCOS patients.

•Protein expression of INSR-β in granulosa cells to differentiate IR and NIR.•Study reveals differential signaling between PCOS-IR and PCOS-NIR.•Decrease in insulin signaling and steroidogenesis in PCOS-IR group.•Decrease only in steroidogenesis in PCOS-NIR group.•Unraveling candidate molecules for target therapy of PCOS phenotypes.