Optimization of non-linear gradient in hydrophobic interaction chromatography for the analytical characterization of antibody-drug conjugates.

Balázs Bobály,Giuseppe Marco Randazzo,Serge Rudaz,Davy Guillarme,Szabolcs Fekete

Journal of Chromatography A（2017）

引用 22|浏览6

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摘要

•A concave logarithmic gradient was optimized for ADC DAR separations in HIC.•The LSS retention model was extended for logarithmic scouting gradients.•The accuracy of retention time prediction was found to be excellent.

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关键词

Hydrophobic interaction chromatography,Antibody-drug-conjugate,Method development,Retention modelling,Non-linear gradient

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