Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia.

Tatjana Pandzic,Jimmy Larsson,Liqun He,Snehangshu Kundu,Kenneth Ban,Muhammad Akhtar-Ali,Anders R Hellström,Anna Schuh,Ruth Clifford,Stuart J Blakemore,Jonathan C Strefford,Tycho Baumann,Armando Lopez-Guillermo,Elias Campo,Viktor Ljungström,Larry Mansouri,Richard Rosenquist,Tobias Sjöblom,Mats Hellström

Clinical cancer research : an official journal of the American Association for Cancer Research（2016）

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摘要

To our knowledge, this is the first forward genetic screen for chemotherapy resistance in CLL. The screen pinpointed novel genes and pathways involved in fludarabine resistance along with previously known resistance mechanisms. Transposon screens can therefore aid interpretation of cancer genome sequencing data in the identification of genes modifying sensitivity to chemotherapy. Clin Cancer Res; 22(24); 6217-27. ©2016 AACR.

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关键词

fludarabine resistance mechanisms,chronic lymphocytic leukemia,mutagenesis

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