Orexin knockout mice exhibit impaired spatial working memory.
Neuroscience Letters（2018）
Abstract
•Knockout of orexin gene impaired mouse spatial working memory in the T-maze task.•Orexin deficiency impaired spatial recognition.•Knockout of orexin gene did not affect the animal’s locomotor activities.
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Key words
Orexin/hypocretin,Spatial working memory,Cognitive function,Locomotor activity
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