Search
ChatPaper
AI Writing
analysis
Analysis
编组
Open Data
more
More
RankingsMust ReadingJournal&ConferenceAI TRAI HistoryMaster Reading TreeXiaomai's Star TalentsTrajectoryTalentNDI TrackerAI sign LanguageOpen
VIPCreated with Sketch.

Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors.

Jeremy M Richter,Daniel L Cheney, J Alex Bates,Anzhi Wei,Joseph M Luettgen,Alan R Rendina,Timothy M Harper,Rangaraj Narayanan,Pancras C Wong,Dietmar Seiffert,Ruth R Wexler,E Scott Priestley

ACS medicinal chemistry letters（2017）

Cited 4|Views31
No score
Abstract
Two novel series of meta-linked phenylglycine-based macrocyclic FVIIa inhibitors have been designed to improve the rodent metabolic stability and PK observed with the precursor para-linked phenylglycine macrocycles. Through iterative structure-based design and optimization, the TF/FVIIa was improved to subnanomolar levels with good clotting activity, metabolic stability, and permeability.
More
Translated text
Key words
FVIIa,anticoagulant,antithrombotic,factor VIIa,macrocycle,thrombosis
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined