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DHEA-induced Ovarian Hyperfibrosis is Mediated by TGF-β Signaling Pathway

Daojuan Wang,Wenqing Wang,Qiao Liang,Xuan He,Yanjie Xia,Shanmei Shen,Hongwei Wang,Qian Gao,Yong Wang

Journal of ovarian research（2018）

Cited 45|Views116
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Abstract
The polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder with pathological mechanisms remain unclear. The following study investigates the ovarian hyperfibrosis forming via transforming growth factor-β (TGF-β) signaling pathway in Dehydroepiandrosterone (DHEA)- induced polycystic ovary syndrome (PCOS) rat model. We furthermore explored whether TGF-βRI inhibitor (SB431542) decreases ovarian fibrosis by counterbalancing the expression of fibrotic biomarkers.
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Key words
Polycystic ovary syndrome,Ovarian hyperfibrosis,TGF-β,SB431542
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