Altered distribution of peripheral blood dendritic cell subsets in patients with pulmonary paracoccidioidomycosis

James Venturini,Ricardo Souza Cavalcante,Daniela Vanessa Moris,Márjorie de Assis Golim,Adriele Dandara Levorato, Karoline Hagatha dos Reis,Maria Sueli Parreira de Arruda,Rinaldo Poncio Mendes

Acta Tropica（2017）

引用 5|浏览23

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摘要

•Paracoccidioidomycosis (PCM) is a systemic fungal disease endemic in Latin America.•Patients usually develop pulmonary sequelae, causing breathing difficulties.•Few studies have addressed the influence of sequelae in the immune response.•Dendritic cells (DC) are important for polarization of the adaptive immune response.•Distribution of myeloid and plasmocytoid DCs is altered in PCM, even after treatment.

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关键词

Paracoccidioides,Plasmacytoid dendritic cells,Myeloid dendritic cells,Antifungal treatment,Pulmonary fibrosis,Emphysema

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