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An enzymatic advance in nicotine cessation therapy.

Song Xue,Marsida Kallupi, Bin Zhou,Lauren C Smith,Pedro O Miranda,Olivier George,Kim D Janda

CHEMICAL COMMUNICATIONS（2018）

Cited 21|Views7
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Abstract
A nicotine-degrading enzyme termed NicA2 was altered (NicA2-J1) through fusion of an albumin binding domain to increase its half-life. Examination of NicA2-J1 in vivo demonstrated a complete blockade of brain nicotine access, which in turn blunted nicotine's psychoactive effects. These data further support development of pharmacokinetic nicotine cessation therapeutics.
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Neuroprotection
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