Bisphenol A stimulates adrenal cortical cell proliferation via ERβ-mediated activation of the sonic hedgehog signalling pathway.
The Journal of Steroid Biochemistry and Molecular Biology（2018）
Abstract
•BPA stimulated cell proliferation in the H295A adrenal cortical cell line.•BPA-induced cell proliferation was a result of activation of the Shh pathway.•BPA activated the Shh signaling pathway through an ERβ-mediated mechanism.
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Key words
BPA,Cell proliferation,ERβ,Shh signaling,Adrenal cortical cells
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