Dropwise additive manufacturing of pharmaceutical products for amorphous and self emulsifying drug delivery systems

International Journal of Pharmaceutics(2017)

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摘要
The improvements in healthcare systems and the advent of the precision medicine initiative have created the need to develop more innovative manufacturing methods for the delivery and production of individualized dosing and personalized treatments. In accordance with the changes observed in healthcare systems towards more innovative therapies, this paper presents dropwise additive manufacturing of pharmaceutical products (DAMPP) for small scale, distributed manufacturing of individualized dosing as an alternative to conventional manufacturing methods A dropwise additive manufacturing process for amorphous and self-emulsifying drug delivery systems is reported, which utilizes drop-on-demand printing technology for automated and controlled deposition of melt-based formulations onto inert tablets.
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关键词
Drug printing,Self-emulsifying drug delivery system,Amorphous,Solid dispersion,Processing,Solid dosage form,Oral drug delivery,Quality by design (QbD),Surfactants
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