Synthesis of xanthan gum graft copolymer and its application for controlled release of highly water soluble Levofloxacin drug in aqueous medium.

•Developed Xanthan gum based graft copolymers of Poly(N-vinyl pyrrolidone).•Graft copolymers are cross-linked sodium alginate, which form 3 dimensional network.•Cross-linked polymers form circular beads which loads highly soluble levofloxacin.•Beads deliver highly soluble levofloxacin with very controlled rate at pH 7.4 & 37°C.