Effect of volume of porogens on the porosity of PLGA scaffolds in pH-controlled environment.

Poly(lactic-co-glycolic acid) (PLGA) is a well-studied biodegradable polymer used in drug delivery and other medical applications such as in tissue regeneration. It is often necessary to impart porosity within the scaffold (microparticles) in order to promote the growth of tissue during the regeneration process. Sodium chloride and ammonium bicarbonate have been extensively used as porogens in the generation of porous microstructure. In this study, we compared the effect of volumes (250l, 500l and 750l) of two porogens, sodium chloride (1.71M) and ammonium bicarbonate (1.71M), on the porosity of PLGA microparticles.