Synthesis of dual responsive carbohydrate polymer based IPN microbeads for controlled release of anti-HIV drug.

•Grafting of poly(N-vinyl caprolactam) on to guar gum back bone.•Dual responsive IPN hydrogel microbeads were developed from sodium alginate and graft copolymer.•In vitro release studies were performed for anti-HIV model drug, Zidovudine.•pH and temperature are key factors during the swelling and drug release studies.