Intramolecular cyclization of diarylmethanols and α,β-unsaturated amides promoted by KOt-Bu/DMF: a metal-free approach towards 3,4-disubstituted quinolinones
Organic & Biomolecular Chemistry(2016)
Abstract
A facile synthesis of quinolinones through intramolecular addition of diarylmethanols to alpha,beta-unsaturated amides promoted by KOt-Bu/DMF is reported. A series of 3,4-disubstituted quinolinones were obtained in moderate to good yields. A reaction pathway via the ketyl radical is proposed.
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Key words
diarylmethanols,intramolecular cyclization,metal-free
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